Deoxyribozymes: New Therapeutics to Treat Central Nervous System Disorders
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چکیده
منابع مشابه
Deoxyribozymes: New Therapeutics to Treat Central Nervous System Disorders
This mini-review focuses on a knockdown technology called deoxyribozymes, which has rarely been utilized in the field of neurobiology/neuroscience. Deoxyribozymes are catalytic DNA molecules, which are also entitled DNA enzyme or DNAzyme. This mini-review presents a description of their development, structure, function, and therapeutic application. In addition, information on siRNA, ribozymes, ...
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The history of drug discovery spans approximately 200,000 years. For much of this time, the identification of therapeutic agents was empirical, with the shift to a more hypothesis-driven approach occurring in the late 19th century. Since then, the objective has changed from identifying an active drug and its mechanism of action to determining therapeutic potential only after identifying drug-li...
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Microparticles (MPs) are a heterogeneous population of small cell-derived vesicles, ranging in size from 0.1 to 1 μ m. They contain a variety of bioactive molecules, including proteins, biolipids, and nucleic acids, which can be transferred between cells without direct cell-to-cell contact. Consequently, MPs represent a novel form of intercellular communication, which could play a role in both...
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Purpose: Neurologic disorders may be seen in patients with cerebral malformations. The aim of this study is determining epilepsy and the other contributing disorders in the patients with cerebral malformations using Gross Motor Function Classification Scale (GMFCS) and Bimanual Fine Motor Function Scale (BFMFS) are used to determine motor function. Methods: The clinical and neuroradiologic feat...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2011
ISSN: 1662-5099
DOI: 10.3389/fnmol.2011.00025